FIBROBLAST GROWTH FACTOR 23 INDUCES LEFT VENTRICULAR HYPERTROPHY
نویسندگان
چکیده
منابع مشابه
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Hemodialysis Patients
Background: Left ventricular hypertrophy (LVH) is a common cardiovascular complication and an independent risk factor for cardiovascular death in hemodialysis (HD) patients. Previous studies have shown that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in HD patients. Objectives: The aim of this study was to determine the association of FG...
متن کاملFibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease.
BACKGROUND Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with mortality. Left ventricular hypertrophy and coronary artery calcification are potent risk factors for mortality in CKD, and FGFs have been implicated in the pathogenesis of both myocardial hypertrop...
متن کاملFibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation
Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an inde...
متن کاملFGF23 induces left ventricular hypertrophy.
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 have been linked to greater risks of LVH and mortality in patients with CKD, but whether these risks represent causal effects of FGF23 is unkno...
متن کاملFGF-23 and Left Ventricular Hypertrophy
Submit Manuscript | http://medcraveonline.com cardiovascular health [1]. Among these FGFs, notably FGF-21 has shown cardio-protective effects such as improving lipoprotein profile, endothelial dysfunction and reducing plaque formation [1]. FGF-23; member of the FGF19 subfamily shows the highest degree of homology with FGF-21 [2,3]. However, contrary to FGF21, elevated levels of the bone-derived...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2012
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(12)61060-2